In Locally Recurrent Breast Cancer (LRBC) and in Malignant Melanoma hyperthermia in combination with radiotherapy is included in leading guidelines:

Breast Cancer


Malignant Melanoma


ESHO Guidelines

    ESHO GuidelinesIn 2017, the European Society of Hyperthermic Oncology has issued quality assurance guidelines:

  • Trefná HD, Crezee H, Schmidt M, Marder D, Lamprecht U, Ehmann M, Hartmann J, Nadobny J, Gellermann J, van Holthe N, Ghadjar P, Lomax N, Abdel-Rahman S, Bert C, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, van Rhoon GC
    Quality assurance guidelines for superficial hyperthermia clinical trials:
    I. Clinical requirements
    Int J Hyperthermia. 2017 Jan 31:1-12
    https://www.ncbi.nlm.nih.gov/pubmed/28049386
  • Dobšíček Trefná H, Crezee J, Schmidt M, Marder D, Lamprecht U, Ehmann M, Nadobny J, Hartmann J, Lomax N, Abdel-Rahman S, Curto S, Bakker A, Hurwitz MD, Diederich CJ, Stauffer PR, Van Rhoon GC
    Quality assurance guidelines for superficial hyperthermia clinical trials:
    II. Technical requirements for heating devices
    Strahlenther Onkol. 2017 May;193(5):351-366
    OPEN ACCESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405104/

  • Water-filtered infrared A is listed as an appropriate and accepted technique. The TWH1500 device is compliant with these requirements.