Literature / Clinical trials
Table of Content:
SELECTED LITERATURE- Depression
- Fibromyalgia
- Oncology
- Chronic inflammation / chronic infection
- Others, general review and overview articles
RUNNING CLINICAL TRIALS USING HECKEL SYSTEMS
Depression
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Clinical studies using heckel WBH systems
Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, Begay TK, Rentscher K, White JJ, Fridman A, Roberts LJ, Robbins ML, Hanusch KU, Cole SP, Raison CL:
Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial
JAMA Psychiatry. 2016 Aug 1;73(8):789-95
https://www.ncbi.nlm.nih.gov/pubmed/27172277
Raison CL, Janssen CW, Lowry CA:
Hyperthermia for Major Depressive Disorder?-Reply.
JAMA Psychiatry. 2016 Oct 1;73(10):1096-1097
https://www.ncbi.nlm.nih.gov/pubmed/27627698
Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL
Whole-Body Hyperthermia for the Treatment of Major Depression: Associations With Thermoregulatory Cooling
Am J Psychiatry 170:7, July 2013
https://www.ncbi.nlm.nih.gov/pubmed/23820835 -
Clinical studies using other WBH techniques
Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R
Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial
BMC Complement Altern Med. 2017; 17: 172
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371197/ -
Reviews, overviews, book chapters
Hanusch KU, Janssen CH
Die Ganzkörperhyperthermie in der Psychiatrie - Eine historische Analyse
[ARTICLE IN GERMAN] Die Naturheilkunde 02/2013
Hanusch KU
“Antidepressive” Effect through Heat Therapy - Influence of the psychical condition of depressive patients through passive whole-body hyperthermia
2012, epubli GmbH, Berlin; ISBN: 978-3-8442-4374-1 (auch deutsche Ausgabe erhältlich)
https://www.epubli.de/shop/buch/The-%22Antidepressive%22-Effect-Of-Passive-Whole-Body-Hyperthermia-Kay-u-Hanusch-9783844243741/23150
Janssen C, Hanusch KU
Passive Ganzkörperhyperthermie bei Depressionen
[ARTICLE IN GERMAN] Die Naturheilkunde 05/2011
Fibromyalgia
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Clinical studies using heckel WBH systems
Romeyke T, Stummer H
Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study
Journal of Musculoskeletal Pain Vol: 22, Issue 4, December 2014, pages 341-355
http://www.tandfonline.com/doi/full/10.3109/10582452.2014.949336
Romeyke T, Scheuer HC, Stummer H
Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy--a prospective controlled study
Clin Interv Aging. 2014 Dec
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279606/
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Clinical studies using other WBH techniques
Brockow T, Wagner A, Franke A, Offenbächer M, Resch KL
A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia.
Clin J Pain. 2007 Jan;23(1):67-75
https://www.ncbi.nlm.nih.gov/pubmed/17277647
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Clinical case reports using heckel WBH systems
Winnicki C, Hanusch KU
Hyperthermie gegen Fibromyalgiesyndrom
Schweiz Z Ganzheitsmed 2013;25:267-268
[ARTICLE IN GERMAN]https://www.karger.com/Article/FullText/355025
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Others
Häuser W, Jung E, Erbslöh-Möller B,Gesmann M, Kühn-Becker H,Petermann F, Langhorst J, Thoma R, Weiss T, Wolfe F, Winkelmann A
The German fibromyalgia consumer reports – a cross-sectional survey
BMC Musculoskelet Disord. 2012; 13: 74
[OPEN ACCESS] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444387/
Oncology (B) extreme WBH
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Clinical studies using heckel WBH systems
Changlin Zhao , Congqi Dai, Xiaoyin Chen
Whole body hyperthermia combined with intraperitoneal chemotherapy for the treatment of stage IV advanced gastric cancer
Int.J.Hyperthermia, December 2012; 28(8): 735-741
https://www.ncbi.nlm.nih.gov/pubmed/23113543
Douwes F, Bogovic J, Douwes O, Migeod F, Grote C
Whole body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer
Int J Clin Oncol. 2004 Apr;9(2):85-91
https://www.ncbi.nlm.nih.gov/pubmed/15108039
Gaworek J, Mayer CT
Systemische Ganzkörperhyperthermie in der Onkologie: Tödliche Hitze für Tumorzellen [Systemic whole body hyperthermia in oncology: fatal heat for tumor cells].
Pflege Z. 2003 Jan;56(1):15-8
[ARTICLE IN GERMAN] http://www.daryan.de/admin/download/file_150.pdf
Reichel M, Scheeren TWL, Douwes O, Konrad RM
Tiefe intravenöse Analgosedierung zur extremen Ganzkörperhyperthermie in Kombination mit Chemotherapie [Deep intravenous analgosedation for extreme whole-body hyperthermia in combination with chemotherapy]
Forum Komplementäre Onkologie & Forum Immunologie, 3/2004, 4-8
[ARTICLE IN GERMAN|OPEN ACCESS] Kombination_mit_Chemotherapie.pdf
Chronic inflammation / chronic infection
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Clinical studies using heckel WBH systems
Zauner D, Quehenberger F, Hermann J, Dejaco C, Stradner M, Stojakovic T, Angerer H, Rinner B, Graninger WB
Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis:A pilot study
Int J Hyperthermia, 2014; 30(6): 393–401
https://www.ncbi.nlm.nih.gov/pubmed/25256892
Fuchs, Y
Effekte einer moderaten Infrarot- Ganzkörper- Hyperthermie auf die Akut- Phase Reaktion
Diplomarbeit Medical University of Graz; 2010. pp. 73
[ARTICLE IN GERMAN|OPEN ACCESS]
https://forschung.medunigraz.at/fodok/suchen.publikationen_mug_autoren?sprache_in=de&menue_id_in=206&id_in=4120&publikation_id_in=103304
Hanusch KU, Janssen CH, Gluch A
Passive Infrarot-A-Ganzkörperhyperthermie (Heckelbett) bei rheumatischen Erkrankungen
Schweiz Z Ganzheitsmed 2011;23:327–330
[ARTICLE IN GERMAN|OPEN ACCESS]
https://www.karger.com/Article/PDF/334700
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Pre-clinical studies
Lee CT, Kokolus KM, Leigh ND, Capitano M, Hylander BL, Repasky EA
Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis
PLoS One. 2015 Mar 20;10(3):e0120327
OPEN ACESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368208/
Reisinger E, Wendelin I, Gasser R, Halwachs G, Wilders-Truschnig M, Krejs
Antibiotics and Increased Temperature against Borrelia burgdorferi in Vitro
Scandinavian Journal of Infectious Diseases, Vol.28, 1996, Issue 2, pp. 155-157
http://www.tandfonline.com/doi/abs/10.3109/00365549609049067
Others, general review and overview articles
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Evans SS, Repasky EA, Fischer DT
Fever and the thermal regulation of immunity: the immune system feels the heat
Nat Rev Immunol. 2015 Jun; 15(6)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/
Kleef R
Hyperthermie und Entgiftung
OM & Ernährung 2011 / Nr.135
[ARTICLE IN GERMAN] http://www.omundernaehrung.com/ausgaben/nr-135.html
Heckel M, Dickreiter B
Ganzkörperhyperthermie – Kontrollierte Erhöhung der Körpertemperatur zu therapeutischen Zwecken
Natur-Heilkunde Journal, 10+11/2007
RUNNING CLINICAL TRIALS USING HECKEL SYSTEMS
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Roswell Park Cancer Institute Buffalo
Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer
https://clinicaltrials.gov/ct2/show/NCT01896778?term=%22Buffalo%22+AND+%22Singh%22&rank=8
Based on these pre-clinical findings:
Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA
Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
Cancer Res. 2011 Jun 1;71(11):3872-80
[OPEN ACCESS] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184616/
Winslow TB, Eranki A, Ullas S, Singh AK, Repasky EA, Sen A
A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
Int J Hyperthermia. 2015 Sep; 31(6): 693–701
First report on the running study:
Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK
Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer
Int J Hyperthermia. 2016 Aug;32(5):539-42, LETTER TO THE EDITOR
https://www.ncbi.nlm.nih.gov/pubmed/27150820