Literature / Clinical trials


Table of Content:

SELECTED LITERATURE

Depression

  1. Clinical studies using heckel WBH systems
    Janssen CW, Lowry CA, Mehl MR, Allen JJ, Kelly KL, Gartner DE, Medrano A, Begay TK, Rentscher K, White JJ, Fridman A, Roberts LJ, Robbins ML, Hanusch KU, Cole SP, Raison CL:
    Whole-Body Hyperthermia for the Treatment of Major Depressive Disorder: A Randomized Clinical Trial
    JAMA Psychiatry. 2016 Aug 1;73(8):789-95
    https://www.ncbi.nlm.nih.gov/pubmed/27172277

    Raison CL, Janssen CW, Lowry CA:
    Hyperthermia for Major Depressive Disorder?-Reply.
    JAMA Psychiatry. 2016 Oct 1;73(10):1096-1097
    https://www.ncbi.nlm.nih.gov/pubmed/27627698

    Hanusch KU, Janssen CH, Billheimer D, Jenkins I, Spurgeon E, Lowry CA, Raison CL
    Whole-Body Hyperthermia for the Treatment of Major Depression: Associations With Thermoregulatory Cooling
    Am J Psychiatry 170:7, July 2013
    https://www.ncbi.nlm.nih.gov/pubmed/23820835

  2. Clinical studies using other WBH techniques
    Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R
    Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial
    BMC Complement Altern Med. 2017; 17: 172
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371197/

  3. Reviews, overviews, book chapters
    Hanusch KU, Janssen CH
    Die Ganzkörperhyperthermie in der Psychiatrie - Eine historische Analyse
    [ARTICLE IN GERMAN] Die Naturheilkunde 02/2013

    Hanusch KU
    “Antidepressive” Effect through Heat Therapy - Influence of the psychical condition of depressive patients through passive whole-body hyperthermia
    2012, epubli GmbH, Berlin; ISBN: 978-3-8442-4374-1 (auch deutsche Ausgabe erhältlich)
    https://www.epubli.de/shop/buch/The-%22Antidepressive%22-Effect-Of-Passive-Whole-Body-Hyperthermia-Kay-u-Hanusch-9783844243741/23150

    Janssen C, Hanusch KU
    Passive Ganzkörperhyperthermie bei Depressionen
    [ARTICLE IN GERMAN] Die Naturheilkunde 05/2011


Fibromyalgia

  1. Clinical studies using heckel WBH systems
    Romeyke T, Stummer H
    Multi-Modal Pain Therapy of Fibromyalgia Syndrome with Integration of Systemic Whole-Body Hyperthermia – Effects on Pain Intensity and Mental State: A Non-Randomised Controlled Study
    Journal of Musculoskeletal Pain Vol: 22, Issue 4, December 2014, pages 341-355
    http://www.tandfonline.com/doi/full/10.3109/10582452.2014.949336

    Romeyke T, Scheuer HC, Stummer H
    Fibromyalgia with severe forms of progression in a multidisciplinary therapy setting with emphasis on hyperthermia therapy--a prospective controlled study
    Clin Interv Aging. 2014 Dec
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279606/

  2. Clinical studies using other WBH techniques
    Brockow T, Wagner A, Franke A, Offenbächer M, Resch KL
    A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia.
    Clin J Pain. 2007 Jan;23(1):67-75
    https://www.ncbi.nlm.nih.gov/pubmed/17277647

  3. Clinical case reports using heckel WBH systems
    Winnicki C, Hanusch KU
    Hyperthermie gegen Fibromyalgiesyndrom
    Schweiz Z Ganzheitsmed 2013;25:267-268
    [ARTICLE IN GERMAN]https://www.karger.com/Article/FullText/355025

  4. Others
    Häuser W, Jung E, Erbslöh-Möller B,Gesmann M, Kühn-Becker H,Petermann F, Langhorst J, Thoma R, Weiss T, Wolfe F, Winkelmann A
    The German fibromyalgia consumer reports – a cross-sectional survey
    BMC Musculoskelet Disord. 2012; 13: 74
    [OPEN ACCESS] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444387/


Oncology (B) extreme WBH

  1. Clinical studies using heckel WBH systems
    Changlin Zhao , Congqi Dai, Xiaoyin Chen
    Whole body hyperthermia combined with intraperitoneal chemotherapy for the treatment of stage IV advanced gastric cancer
    Int.J.Hyperthermia, December 2012; 28(8): 735-741
    https://www.ncbi.nlm.nih.gov/pubmed/23113543

    Douwes F, Bogovic J, Douwes O, Migeod F, Grote C
    Whole body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer
    Int J Clin Oncol. 2004 Apr;9(2):85-91
    https://www.ncbi.nlm.nih.gov/pubmed/15108039

    Gaworek J, Mayer CT
    Systemische Ganzkörperhyperthermie in der Onkologie: Tödliche Hitze für Tumorzellen [Systemic whole body hyperthermia in oncology: fatal heat for tumor cells].
    Pflege Z. 2003 Jan;56(1):15-8
    [ARTICLE IN GERMAN] http://www.daryan.de/admin/download/file_150.pdf

    Reichel M, Scheeren TWL, Douwes O, Konrad RM
    Tiefe intravenöse Analgosedierung zur extremen Ganzkörperhyperthermie in Kombination mit Chemotherapie [Deep intravenous analgosedation for extreme whole-body hyperthermia in combination with chemotherapy]
    Forum Komplementäre Onkologie & Forum Immunologie, 3/2004, 4-8
    [ARTICLE IN GERMAN|OPEN ACCESS] Kombination_mit_Chemotherapie.pdf


Chronic inflammation / chronic infection

  1. Clinical studies using heckel WBH systems
    Zauner D, Quehenberger F, Hermann J, Dejaco C, Stradner M, Stojakovic T, Angerer H, Rinner B, Graninger WB
    Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis:A pilot study
    Int J Hyperthermia, 2014; 30(6): 393–401
    https://www.ncbi.nlm.nih.gov/pubmed/25256892

    Fuchs, Y
    Effekte einer moderaten Infrarot- Ganzkörper- Hyperthermie auf die Akut- Phase Reaktion
    Diplomarbeit Medical University of Graz; 2010. pp. 73
    [ARTICLE IN GERMAN|OPEN ACCESS]
    https://forschung.medunigraz.at/fodok/suchen.publikationen_mug_autoren?sprache_in=de&menue_id_in=206&id_in=4120&publikation_id_in=103304

    Hanusch KU, Janssen CH, Gluch A
    Passive Infrarot-A-Ganzkörperhyperthermie (Heckelbett) bei rheumatischen Erkrankungen
    Schweiz Z Ganzheitsmed 2011;23:327–330
    [ARTICLE IN GERMAN|OPEN ACCESS]
    https://www.karger.com/Article/PDF/334700

  2. Pre-clinical studies
    Lee CT, Kokolus KM, Leigh ND, Capitano M, Hylander BL, Repasky EA
    Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis
    PLoS One. 2015 Mar 20;10(3):e0120327
    OPEN ACESS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368208/

    Reisinger E, Wendelin I, Gasser R, Halwachs G, Wilders-Truschnig M, Krejs
    Antibiotics and Increased Temperature against Borrelia burgdorferi in Vitro
    Scandinavian Journal of Infectious Diseases, Vol.28, 1996, Issue 2, pp. 155-157
    http://www.tandfonline.com/doi/abs/10.3109/00365549609049067


Others, general review and overview articles



RUNNING CLINICAL TRIALS USING HECKEL SYSTEMS

  • Roswell Park Cancer Institute Buffalo
    Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer
    https://clinicaltrials.gov/ct2/show/NCT01896778?term=%22Buffalo%22+AND+%22Singh%22&rank=8

    Based on these pre-clinical findings:

    Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, Evans SS, Hylander BL, Repasky EA
    Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
    Cancer Res. 2011 Jun 1;71(11):3872-80
    [OPEN ACCESS] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184616/

    Winslow TB, Eranki A, Ullas S, Singh AK, Repasky EA, Sen A
    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
    Int J Hyperthermia. 2015 Sep; 31(6): 693–701

    First report on the running study:

    Rich LJ, Winslow TB, Alberico RA, Repasky EA, Seshadri M, Singh AK
    Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer
    Int J Hyperthermia. 2016 Aug;32(5):539-42, LETTER TO THE EDITOR
    https://www.ncbi.nlm.nih.gov/pubmed/27150820